Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells.

Nucleic acids research - 1 Mar 2012

Arakawa Hiroshi, Bednar Theresa, Wang Minli, Paul Katja, Mladenov Emil, Bencsik-Theilen Alena A, Iliakis George

Abstract excerpt

In eukaryotes, the three families of ATP-dependent DNA ligases are associated with specific functions in DNA metabolism. DNA ligase I (LigI) catalyzes Okazaki-fragment ligation at the replication fork and nucleotide excision repair (NER). DNA ligase IV (LigIV) mediates repair of DNA double strand breaks (DSB) via the canonical non-homologous end-joining (NHEJ) pathway. The evolutionary younger DNA ligase III...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Ligase ATP
Share to DNA Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Gene Knockout Techniques

Share to Gene Targeting

Share to Genes, Lethal

Share to Poly-ADP-Ribose Binding Proteins

Share to Xenopus Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22127868
DOI: 10.1093/nar/gkr1024
PMCID: PMC3315315

Genes

LIG1
LIG3
LIG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells.PMID 22127868Read ↗

DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency.Semantic proximity Read ↗

DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates.Semantic proximity Read ↗

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair.Semantic proximity Read ↗

Altered DNA ligase activity in human diseaseSemantic proximity Read ↗

Mitochondrial DNA ligase is dispensable for the viability of cultured cells but essential for mtDNA maintenance.Semantic proximity Read ↗

DNA ligase IV mutations confer shorter lifespan and increased sensitivity to nutrient stress in Drosophila melanogaster.Semantic proximity Read ↗

Early embryonic lethality due to targeted inactivation of DNA ligase III.Semantic proximity Read ↗

Ligase IV syndrome.Semantic proximity Read ↗

Structure and function of the DNA ligases encoded by the mammalian LIG3 geneSemantic proximity Read ↗

Completion of base excision repair by mammalian DNA ligases.Semantic proximity Read ↗

A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks.Semantic proximity Read ↗

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.