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Article

Structure of trypanosome coat protein VSGsur and function in suramin resistance.

Nature microbiology - 1 Mar 2021

Zeelen Johan, van Straaten Monique, Verdi Joseph, Hempelmann Alexander, Hashemi Hamidreza, Perez Kathryn, Jeffrey Philip D, Hälg Silvan, Wiedemar Natalie, Mäser Pascal, Papavasiliou F Nina, Stebbins C Erec

Abstract excerpt

Suramin has been a primary early-stage treatment for African trypanosomiasis for nearly 100 yr. Recent studies revealed that trypanosome strains that express the variant surface glycoprotein (VSG) VSGsur possess heightened resistance to suramin. Here, we show that VSGsur binds tightly to suramin but other VSGs do not. By solving high-resolution crystal structures of VSGsur and VSG13, we also demonstrate that...

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Share to Antigenic Variation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33462435
DOI: 10.1038/s41564-020-00844-1
PMCID: PMC7116837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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