Article

The major diagnostic VSG LiTat 1.3 of the human parasite <i>Trypanosoma brucei gambiense</i> is a trimer in solution

2025-10-28

Abstract excerpt

Human African trypanosomiasis (HAT) remains a significant health burden in sub-Saharan Africa, with serological diagnosis relying heavily on parasite variant surface glycoproteins (VSGs). In this study, we present evidence that LiTat 1.3 (a key VSG in the diagnosis of T. b. gambiense infections) displays a homotrimeric architecture in solution instead of the archetypal homodimeric structure expected for a VSG. Th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54afcfce-d61c-5b2e-921f-a1a985480791
DOI: 10.1101/2025.10.28.684996

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The major diagnostic VSG LiTat 1.3 of the human parasite <i>Trypanosoma brucei gambiense</i> is a trimer in solutionDOI 10.1101/2025.10.28.684996Read

Biological and demographic causes of high HIV and sexually transmitted disease prevalence in men who have sex with menSemantic proximity Read

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat.Semantic proximity Read

VSGs expressed during natural <i>T. b. gambiense</i> infection exhibit extensive sequence divergence and a subspecies-specific expression biasSemantic proximity Read

Targets of the human antibody response to the variant surface glycoprotein of <i>Trypanosoma brucei</i>Semantic proximity Read

Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.Semantic proximity Read

Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families.Semantic proximity Read

A Host-Pathogen Interaction Reduced to First Principles: Antigenic Variation in T. brucei.Semantic proximity Read

Architecture of a Host–Parasite Interface: Complex Targeting Mechanisms Revealed Through ProteomicsSemantic proximity Read

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide <i>Trypanosoma brucei</i> VSG expressionSemantic proximity Read

Variant surface glycoprotein diversity in African trypanosomesSemantic proximity Read

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei.Semantic proximity Read

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of VulnerabilitySemantic proximity Read