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Article

Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection.

Viruses - 17 Mar 2020

Albulescu Irina C, White-Scholten Leonie, Tas Ali, Hoornweg Tabitha E, Ferla Salvatore, Kovacikova Kristina, Smit Jolanda M, Brancale Andrea, Snijder Eric J, van Hemert Martijn J

Abstract excerpt

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause a debilitating disease that is primarily characterized by persistent joint pain. CHIKV has been emerging globally, while neither a vaccine nor antiviral medication is available. The anti-parasitic drug suramin was previously shown to inhibit CHIKV replication. In this study we aimed to obtain more detailed insight into its mechanism of...

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Identifiers

PMID: 32191995
DOI: 10.3390/v12030314
PMCID: PMC7150963

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