Association of TMEM106B rs1990622 marker and frontotemporal dementia: evidence for a recessive effect and meta-analysis.

doi:10.3233/JAD-132432

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Article

Association of TMEM106B rs1990622 marker and frontotemporal dementia: evidence for a recessive effect and meta-analysis.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Hernández Isabel, Rosende-Roca Maitée, Alegret Montserrat, Mauleón Ana, Espinosa Ana, Vargas Liliana, Sotolongo-Grau Oscar, Tárraga Lluís, Boada Mercè, Ruiz Agustín

Abstract excerpt

Transmembrane Protein 106B SNP rs1990622 was recently shown to modify the risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTD-TDP). An independent replication study of this genetic variant was performed in 381 individuals from Catalonia (Spain). By applying a recessive model, a tendency toward an association with FTD risk was observed in our case-control study (age- and gender-adjusted odds...

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PMID: 25096617
DOI: 10.3233/JAD-132432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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