Article

<i>mlh3</i> separation of function and endonuclease defective mutants display an unexpected effect on meiotic recombination outcomes

2017-02-14

Abstract excerpt

Mlh1-Mlh3 is an endonuclease hypothesized to act in meiosis to resolve double Holliday junctions into crossovers. It also plays a minor role in eukaryotic DNA mismatch repair (MMR). To understand how Mlh1-Mlh3 functions in both meiosis and MMR, we analyzed in baker’s yeast 60 new mlh3 alleles. Five alleles specifically disrupted MMR, whereas one ( mlh3-32 ) specifically disrupted meiotic crossing over. Mlh1-mlh3...

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Literature Corpus work: 25d25eab-14ae-55b2-9248-c932152446f2
DOI: 10.1101/108498

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