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Article

exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair.

Molecular and cellular biology - 1 Aug 2001

Amin N S, Nguyen M N, Oh S, Kolodner R D

Abstract excerpt

EXO1 interacts with MSH2 and MLH1 and has been proposed to be a redundant exonuclease that functions in mismatch repair (MMR). To better understand the role of EXO1 in mismatch repair, a genetic screen was performed to identify mutations that increase the mutation rates caused by weak mutator mutations such as exo1Delta and pms1-A130V mutations. In a screen starting with an exo1 mutation, exo1-dependent mutator...

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Topics

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Share to Adenosine Triphosphate
Share to Base Pair Mismatch
Share to Exodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Complementation Test

Share to Nucleic Acid Conformation

Share to Proliferating Cell Nuclear Antigen

Share to Suppression, Genetic

Source

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Identifiers

PMID: 11438669
DOI: 10.1128/MCB.21.15.5142-5155.2001
PMCID: PMC87239

Genes

MLH1
EXO1
MSH2
PMS1
MSH3
PCNA
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair.PMID 11438669Read ↗

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