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Article

Homologous recombination counteracts mismatch repair to promote fertility and genetic diversity.

Trends in genetics : TIG - 1 Jan 2026

Wang Ting-Fang, Liao Ji-Long

Abstract excerpt

The DNA mismatch repair (MMR) system is classically viewed as being anti-recombinogenic during meiosis because it mediates heteroduplex rejection to inhibit homeologous recombination, leading to postzygotic isolation between closely related species. In this forum article, conversely, we summarize a very recent study showing that homologous recombination (HR) proteins can antagonize MMR.

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PMID: 41241584
DOI: 10.1016/j.tig.2025.10.009

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