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The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination

15 Jul 2002

Abstract excerpt

The mismatch-repair (MMR) system plays a central role in maintaining genetic stability and requires evolutionarily conserved protein factors, including MutS and MutL homologs. Since the discovery of a link between the malfunction of post-replicative MMR and human cancers, a number of works have focused on the function of MutS and MutL homologs in the correction of replication errors. However, several MutS-like...

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PMID: 12095912
DOI: 10.1093/hmg/11.15.1697

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The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombinationPMID 12095912Read ↗

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Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombinationSemantic proximity Read ↗

A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.Semantic proximity Read ↗

Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.Semantic proximity Read ↗

Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination.Semantic proximity Read ↗

Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.Semantic proximity Read ↗

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