Article
A role for human homologous recombination factors in suppressing microhomology-mediated end joining.
Nucleic acids research - 8 Jul 2016
Ahrabi Sara, Sarkar Sovan, Pfister Sophia X, Pirovano Giacomo, Higgins Geoff S, Porter Andrew C G, Humphrey Timothy C
Abstract excerpt
DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pathway, microhomology-mediated end joining (MMEJ), can also be deployed. While MMEJ is suppressed by C-NHEJ, the...
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