Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans.

PLoS biology - 1 Apr 2017

Manhart Carol M, Ni Xiaodan, White Martin A, Ortega Joaquin, Surtees Jennifer A, Alani Eric

Abstract excerpt

Crossing over between homologs is initiated in meiotic prophase by the formation of DNA double-strand breaks that occur throughout the genome. In the major interference-responsive crossover pathway in baker's yeast, these breaks are resected to form 3' single-strand tails that participate in a homology search, ultimately forming double Holliday junctions (dHJs) that primarily include both homologs. These dHJs are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Breaks, Double-Stranded
Share to DNA, Circular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Proteins

Share to MutS Homolog 2 Protein

Share to MutS Homolog 3 Protein

Share to Proliferating Cell Nuclear Antigen

Share to Replication Protein C

Source

Open in PubMed Open full text

Identifiers

PMID: 28453523
DOI: 10.1371/journal.pbio.2001164
PMCID: PMC5409509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans.PMID 28453523Read ↗

<i>mlh3</i> separation of function and endonuclease defective mutants display an unexpected effect on meiotic recombination outcomesSemantic proximity Read ↗

mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.Semantic proximity Read ↗

Regulation of the MLH1-MLH3 endonuclease in meiosisSemantic proximity Read ↗

Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination.Semantic proximity Read ↗

Coordinated and Independent Roles for MLH Subunits in DNA RepairSemantic proximity Read ↗

A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Mlh1-Pms1 endonuclease uses ATP to preserve DNA discontinuities as strand discrimination signals to facilitate mismatch repairSemantic proximity Read ↗

Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast.Semantic proximity Read ↗

A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.Semantic proximity Read ↗

Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules.Semantic proximity Read ↗

Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.