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Article

CROP: a CRISPR/Cas9 guide selection program based on mapping guide variants.

Scientific reports - 15 Jan 2021

Aprilyanto Victor, Aditama Redi, Tanjung Zulfikar Achmad, Utomo Condro, Liwang Tony

Abstract excerpt

The off-target effect, in which DNA cleavage was conducted outside the targeted region, is a major problem which limits the applications of CRISPR/Cas9 genome editing system. CRISPR Off-target Predictor (CROP) is standalone program developed to address this problem by predicting off-target propensity of guide RNAs and thereby allowing the user to select the optimum guides. The approach used by CROP involves...

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Identifiers

PMID: 33452424
DOI: 10.1038/s41598-021-81297-2
PMCID: PMC7811000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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