Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

crisprSQL: a novel database platform for CRISPR/Cas off-target cleavage assays

17 Oct 2020

Abstract excerpt

With ongoing development of the CRISPR/Cas programmable nuclease system, applications in the area of in vivo therapeutic gene editing are increasingly within reach. However, non-negligible off-target effects remain a major concern for clinical applications. Even though a multitude of off-target cleavage datasets have been published, a comprehensive, transparent overview tool has not yet been established. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to RNA and protein synthesis mechanisms
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33084893
DOI: 10.1093/nar/gkaa885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

crisprSQL: a novel database platform for CRISPR/Cas off-target cleavage assaysPMID 33084893Read ↗

High-throughput evaluation of in vitro CRISPR activities enables optimized large-scale multiplex enrichment of rare variants.Semantic proximity Read ↗

piCRISPR: Physically Informed Deep Learning Models for CRISPR/Cas9 Off-Target Cleavage PredictionSemantic proximity Read ↗

CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems.Semantic proximity Read ↗

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target SitesSemantic proximity Read ↗

CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS dataSemantic proximity Read ↗

Defining genome-wide CRISPR–Cas genome-editing nuclease activity with GUIDE-seqSemantic proximity Read ↗

SNIPSNP: precision design of CRISPR/Cas9 knock-in reagents for variant correction and disease modeling.Semantic proximity Read ↗

Towards best-practice approaches for CRISPR/Cas9 gene engineeringSemantic proximity Read ↗

Advances in detecting and reducing off-target effects generated by CRISPR-mediated genome editingSemantic proximity Read ↗

Quantifying allele-specific CRISPR editing activity with CRISPECTOR2.0.Semantic proximity Read ↗

Biased and Unbiased Methods for the Detection of Off-Target Cleavage by CRISPR/Cas9: An OverviewSemantic proximity Read ↗

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.