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Article

Improving CRISPR-Cas9 On-Target Specificity.

Current issues in molecular biology - 1 Jan 2018

Jamal Muhammad, Ullah Arif, Ahsan Muhammad, Tyagi Rohit, Habib Zeshan, Rehman Khaista

Abstract excerpt

The CRISPR-Cas9 has revolutionized the field of molecular biology, medical genetics and medicine. The technology is robust, facile and simple to achieve genome targeting in cells and organisms. However, to propagate these nucleases for therapeutic application, the on-target specificity is of paramount importance. Although the binding and cleavage of off-target sites by Cas9 is issue of concern, however the...

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PMID: 28879857
DOI: 10.21775/cimb.026.065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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