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Article

Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases.

Biotechnology advances - 1 Jan 2000

Zischewski Julia, Fischer Rainer, Bortesi Luisa

Abstract excerpt

The development of customizable sequence-specific nucleases such as TALENs, ZFNs and the powerful CRISPR/Cas9 system has revolutionized the field of genome editing. The CRISPR/Cas9 system is particularly versatile and has been applied in numerous species representing all branches of life. Regardless of the target organism, all researchers using sequence-specific nucleases face similar challenges: confirmation of...

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PMID: 28011075
DOI: 10.1016/j.biotechadv.2016.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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