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Article

Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity.

Molecular cell - 4 Aug 2016

Tycko Josh, Myer Vic E, Hsu Patrick D

Abstract excerpt

Advances in the development of delivery, repair, and specificity strategies for the CRISPR-Cas9 genome engineering toolbox are helping researchers understand gene function with unprecedented precision and sensitivity. CRISPR-Cas9 also holds enormous therapeutic potential for the treatment of genetic disorders by directly correcting disease-causing mutations. Although the Cas9 protein has been shown to bind and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27494557
DOI: 10.1016/j.molcel.2016.07.004
PMCID: PMC4976696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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