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COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

1 Jan 2014

Abstract excerpt

Precise genome editing using engineered nucleases can significantly facilitate biological studies and disease treatment. In particular, clustered regularly interspaced short palindromic repeats (CRISPR) with CRISPR-associated (Cas) proteins are a potentially powerful tool for modifying a genome by targeted cleavage of DNA sequences complementary to designed guide strand RNAs. Although CRISPR/Cas systems can have...

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PMID: 25462530
DOI: 10.1038/mtna.2014.64

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