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Article

Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.

Journal of lipid research - 1 Sept 2008

Hughes Adam L, Stewart Emerson V, Espenshade Peter J

Abstract excerpt

The endoplasmic reticulum membrane protein SREBP cleavage-activating protein (Scap) senses sterols and regulates activation of sterol-regulatory element binding proteins (SREBPs), membrane-bound transcription factors that control lipid homeostasis in fission yeast and mammals. Transmembrane segme...

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Identifiers

PMID: 18503029
DOI: 10.1194/jlr.M800207-JLR200
PMCID: PMC2515523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18503029-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.PMID 18503029Read ↗

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