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Article

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.

The Journal of biological chemistry - 15 Jul 2005

Sun Li-Ping, Li Lu, Goldstein Joseph L, Brown Michael S

Abstract excerpt

When added to living cells, sterols such as cholesterol and 25-hydroxycholesterol block the lateral movement of sterol regulatory element-binding proteins (SREBPs) into COPII-coated vesicles on endoplasmic reticulum (ER) membranes and thereby prevent the SREBPs from reaching the Golgi complex for processing to the mature forms that activate cholesterol synthesis. Sorting of SREBPs into COPII vesicles is mediated...

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Identifiers

PMID: 15899885
DOI: 10.1074/jbc.M504041200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.PMID 15899885Read ↗

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A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.Semantic proximity Read ↗

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