Article
SCAP is required for timely and proper myelin membrane synthesis.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2009
Verheijen Mark H G, Camargo Nutabi, Verdier Valerie, Nadra Karim, de Preux Charles Anne-Sophie, Médard Jean-Jacques, Luoma Adrienne, Crowther Michelle, Inouye Hideyo, Shimano Hitoshi, Chen Su, Brouwers Jos F, Helms J Bernd, Feltri M Laura, Wrabetz Lawrence, Kirschner Daniel, Chrast Roman, Smit August B
Abstract excerpt
Myelination requires a massive increase in glial cell membrane synthesis. Here, we demonstrate that the acute phase of myelin lipid synthesis is regulated by sterol regulatory element-binding protein (SREBP) cleavage activation protein (SCAP), an activator of SREBPs. Deletion of SCAP in Schwann cells led to a loss of SREBP-mediated gene expression involving cholesterol and fatty acid synthesis. Schwann cell SCAP...
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