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Article

WNKs are potassium-sensitive kinases.

American journal of physiology. Cell physiology - 1 May 2021

Pleinis John M, Norrell Logan, Akella Radha, Humphreys John M, He Haixia, Sun Qifei, Zhang Feng, Sosa-Pagan Jason, Morrison Daryl E, Schellinger Jeffrey N, Jackson Laurie K, Goldsmith Elizabeth J, Rodan Aylin R

Abstract excerpt

With no lysine (K) (WNK) kinases regulate epithelial ion transport in the kidney to maintain homeostasis of electrolyte concentrations and blood pressure. Chloride ion directly binds WNK kinases to inhibit autophosphorylation and activation. Changes in extracellular potassium are thought to regulate WNKs through changes in intracellular chloride. Prior studies demonstrate that in some distal nephron epithelial...

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Identifiers

PMID: 33439774
DOI: 10.1152/ajpcell.00456.2020
PMCID: PMC8163576

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