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Article

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.

American journal of physiology. Cell physiology - 1 Jul 2016

Mercado Adriana, de Los Heros Paola, Melo Zesergio, Chávez-Canales María, Murillo-de-Ozores Adrián R, Moreno Erika, Bazúa-Valenti Silvana, Vázquez Norma, Hadchouel Juliette, Gamba Gerardo

Abstract excerpt

The K(+)-Cl(-) cotransporters (KCC1-KCC4) encompass a branch of the SLC12 family of electroneutral cation-coupled chloride cotransporters that translocate ions out of the cell to regulate various factors, including cell volume and intracellular chloride concentration, among others. L-WNK1 is an ubiquitously expressed kinase that is activated in response to osmotic stress and intracellular chloride depletion, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27170636
DOI: 10.1152/ajpcell.00193.2015
PMCID: PMC4967140

Genes

WNK1
OSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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