Article
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.
Nature genetics - 1 Oct 2006
Lalioti Maria D, Zhang Junhui, Volkman Heather M, Kahle Kristopher T, Hoffmann Kristin E, Toka Hakan R, Nelson-Williams Carol, Ellison David H, Flavell Richard, Booth Carmen J, Lu Yin, Geller David S, Lifton Richard P
Abstract excerpt
The mechanisms that govern homeostasis of complex systems have been elusive but can be illuminated by mutations that disrupt system behavior. Mutations in the gene encoding the kinase WNK4 cause pseudohypoaldosteronism type II (PHAII), a syndrome featuring hypertension and hyperkalemia. We show that physiology in mice transgenic for genomic segments harboring wild-type (TgWnk4(WT)) or PHAII mutant (TgWnk4(PHAII))...
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