Article
WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.
Kidney international - 1 Aug 2006
Subramanya A R, Yang C-L, McCormick J A, Ellison D H
Abstract excerpt
With-No-Lysine [K] (WNKs) are a recently discovered family of serine/threonine protein kinases that contain a uniquely structured catalytic domain. Mutations in the genes encoding two family members, WNK1 and WNK4, cause a chloride-dependent, thiazide-sensitive inherited syndrome of hypertension and hyperkalemia. Over the past 5 years, physiologic studies have demonstrated that these proteins regulate...
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