Article
WNKs: protein kinases with a unique kinase domain.
Experimental & molecular medicine - 31 Oct 2007
Huang Chou Long, Cha Seung Kuy, Wang Hao Ran, Xie Jian, Cobb Melanie H
Abstract excerpt
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion transport were first revealed by the findings that mutations of two members cause a genetic hypertension and hyperkalemia syndrome. More recent studies suggest that WNKs are pleiotropic protein kinases with...
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