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Article

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006

Lazrak Ahmed, Liu Zhen, Huang Chou-Long

Abstract excerpt

WNK kinases are serine-threonine kinases with an atypical placement of the catalytic lysine. Intronic deletions with increased expression of a ubiquitous long WNK1 transcript cause pseudohypoaldosteronism type 2 (PHA II), characterized by hypertension and hyperkalemia. Here, we report that long WNK1 inhibited ROMK1 by stimulating its endocytosis. Inhibition of ROMK by long WNK1 was synergistic with, but not...

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Source

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Identifiers

PMID: 16428287
DOI: 10.1073/pnas.0510609103
PMCID: PMC1360592

Genes

WNK1
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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