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Article

Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.

Biochimica et biophysica acta - 1 Dec 2010

Kahle Kristopher T, Rinehart Jesse, Lifton Richard P

Abstract excerpt

Precise regulation of the intracellular concentration of chloride [Cl-]i is necessary for proper cell volume regulation, transepithelial transport, and GABA neurotransmission. The Na-K-2Cl (NKCCs) and K-Cl (KCCs) cotransporters, related SLC12A transporters mediating cellular chloride influx and efflux, respectively, are key determinants of [Cl-]i in numerous cell types, including red blood cells, epithelial...

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Source

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Identifiers

PMID: 20637866
DOI: 10.1016/j.bbadis.2010.07.009
PMCID: PMC3529164

Genes

OSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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