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Article

Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.

American journal of physiology. Renal physiology - 1 Aug 2018

Wu Peng, Gao Zhong-Xiuzi, Su Xiao-Tong, Ellison David H, Hadchouel Juliette, Teulon Jacques, Wang Wen-Hui

Abstract excerpt

With-no-lysine kinase 4 (WNK4) and kidney-specific (KS)-WNK1 regulate ROMK (Kir1.1) channels in a variety of cell models. We now explore the role of WNK4 and KS-WNK1 in regulating ROMK in the native distal convoluted tubule (DCT)/connecting tubule (CNT) by measuring tertiapin-Q (TPNQ; ROMK inhibitor)-sensitive K+ currents with whole cell recording. TPNQ-sensitive K+ currents in DCT2/CNT of KS- WNK1-/- and WNK4-/-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kidney Tubules, Distal

Share to Membrane Potentials

Share to Potassium Channels, Inwardly Rectifying

Share to Protein Serine-Threonine Kinases

Share to WNK Lysine-Deficient Protein Kinase 1

Source

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Identifiers

PMID: 29667910
DOI: 10.1152/ajprenal.00050.2018
PMCID: PMC6139523

Genes

WNK1
WNK4
DCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.PMID 29667910Read ↗

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