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Article

Cell-specific regulation of L-WNK1 by dietary K.

American journal of physiology. Renal physiology - 1 Jan 2016

Webb Tennille N, Carrisoza-Gaytan Rolando, Montalbetti Nicolas, Rued Anna, Roy Ankita, Socovich Alexandra M, Subramanya Arohan R, Satlin Lisa M, Kleyman Thomas R, Carattino Marcelo D

Abstract excerpt

Flow-induced K(+) secretion in the aldosterone-sensitive distal nephron is mediated by high-conductance Ca(2+)-activated K(+) (BK) channels. Familial hyperkalemic hypertension (pseudohypoaldosteronism type II) is an inherited form of hypertension with decreased K(+) secretion and increased Na(+) reabsorption. This disorder is linked to mutations in genes encoding with-no-lysine kinase 1 (WNK1), WNK4, and...

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Share to Gene Expression Regulation, Enzymologic
Share to Kidney Tubules, Collecting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Large-Conductance Calcium-Activated Potassium Channel alpha Subunits

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Share to WNK Lysine-Deficient Protein Kinase 1

Source

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Identifiers

PMID: 26662201
DOI: 10.1152/ajprenal.00226.2015
PMCID: PMC4675801

Genes

WNK1
WNK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Cell-specific regulation of L-WNK1 by dietary K.PMID 26662201Read ↗

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WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.Semantic proximity Read ↗

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse modelsSemantic proximity Read ↗

Human hypertension caused by mutations in WNK kinases.Semantic proximity Read ↗

Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.Semantic proximity Read ↗

WNK kinases and the kidney.Semantic proximity Read ↗

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.Semantic proximity Read ↗

WNKs are potassium-sensitive kinases.Semantic proximity Read ↗

WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.Semantic proximity Read ↗

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.Semantic proximity Read ↗

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.Semantic proximity Read ↗

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