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Article

Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis.

Kidney international - 1 Jan 2016

Terker Andrew S, Zhang Chong, Erspamer Kayla J, Gamba Gerardo, Yang Chao-Ling, Ellison David H

Abstract excerpt

Dietary potassium deficiency activates thiazide-sensitive sodium chloride cotransport along the distal nephron. This may explain, in part, the hypertension and cardiovascular mortality observed in individuals who consume a low-potassium diet. Recent data suggest that plasma potassium affects the distal nephron directly by influencing intracellular chloride, an inhibitor of the with-no-lysine kinase...

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Share to Chlorides
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Share to Kidney Tubules, Distal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Solute Carrier Family 12, Member 3

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Source

Open in PubMed Open full text

Identifiers

PMID: 26422504
DOI: 10.1038/ki.2015.289
PMCID: PMC4814375

Genes

WNK4
WNK1
WNK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis.PMID 26422504Read ↗

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