Article
Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia.
Molecular brain - 22 Oct 2008
Takao Keizo, Toyama Keiko, Nakanishi Kazuo, Hattori Satoko, Takamura Hironori, Takeda Masatoshi, Miyakawa Tsuyoshi, Hashimoto Ryota
Abstract excerpt
BACKGROUND: Schizophrenia is a complex genetic disorder caused by multiple genetic and environmental factors. The dystrobrevin-binding protein 1 (DTNBP1: dysbindin-1) gene is a major susceptibility gene for schizophrenia. Genetic variations in DTNBP1 are associated with cognitive functions, general cognitive ability and memory function, and clinical features of patients with schizophrenia including negative...
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