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<i>Cbs</i> overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with <i>Dyrk1a</i>

2018-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Identifying dosage sensitive genes is a key to understand the mechanisms underlying intellectual disability in Down syndrome (DS). The Dp(17Abcg1-Cbs)1Yah DS mouse model (Dp1Yah) show cognitive phenotype and needs to be investigated to identify the main genetic driver. Here, we report that, in the Dp1Yah mice, 3 copies of the Cystathionine-beta-synthase gene ( Cbs) are necessary to observe a de...

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Literature Corpus work
5bfeb010-4ad8-52d3-b78a-302c87607f20
DOI
10.1101/393579
Open publication

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<i>Cbs</i> overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with <i>Dyrk1a</i>DOI 10.1101/393579
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