Article
Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A).
PloS one - 2 Jul 2008
Arqué Glòria, Fotaki Vassiliki, Fernández David, Martínez de Lagrán María, Arbonés Maria L, Dierssen Mara
Abstract excerpt
BACKGROUND: Pathogenic aneuploidies involve the concept of dosage-sensitive genes leading to over- and underexpression phenotypes. Monosomy 21 in human leads to mental retardation and skeletal, immune and respiratory function disturbances. Most of the human condition corresponds to partial monoso...
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