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Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer's Disease by Binding with Catalase.

Oxidative medicine and cellular longevity - 1 Jan 2020

Jiang Wenjing, YanYu, Yao Dandan, Fei Xuechao, Ai Li, Di Yalan, Zhang Jingnan, Yue Xiangpei, Zhao Shengjie, He Rongqiao, Lyu Jihui, Tong Zhiqian

Abstract excerpt

Amyloid-beta (Aβ) is a critical etiological factor for late-onset familial Alzheimer's disease (AD). However, an early-onset AD has been found to be related with an Aβ mutation in glutamic acid 22-to-lysine (Italian type E22K). Why only one single point mutation at E22 residue induces AD remains unclear. Here, we report that a Chinese familial AD pedigree with E22K mutation was associated with higher levels of...

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Identifiers

PMID: 33425208
DOI: 10.1155/2020/4981204
PMCID: PMC7775154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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