Article
Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies.
PloS one - 1 Jan 2012
Chen Wei-Ting, Hong Chen-Jee, Lin Ya-Tzu, Chang Wen-Han, Huang He-Ting, Liao Jhih-Ying, Chang Yu-Jen, Hsieh Yi-Fang, Cheng Chih-Ya, Liu Hsiu-Chih, Chen Yun-Ru, Cheng Irene H
Abstract excerpt
Amyloid precursor protein (APP) mutations associated with familial Alzheimer's disease (AD) usually lead to increases in amyloid β-protein (Aβ) levels or aggregation. Here, we identified a novel APP mutation, located within the Aβ sequence (Aβ(D7H)), in a Taiwanese family with early onset AD and explored the pathogenicity of this mutation. Cellular and biochemical analysis reveal that this mutation increased Aβ...
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