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Article

The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease.

Geriatrics & gerontology international - 1 Jul 2010

Murakami Kazuma, Masuda Yuichi, Shirasawa Takuji, Shimizu Takahiko, Irie Kazuhiro

Abstract excerpt

One hallmark of Alzheimer's disease (AD) is the accumulation of amyloid beta (Abeta) peptides in the brain; Abeta mainly consists of 42-mer and 40-mer peptides (Abeta42 and Abeta40). Abeta42 plays a more critical role in the pathogenesis of AD because Abeta42 aggregates much faster and is more toxic than Abeta40. Therefore, there is an urgent need to elucidate the mechanism of aggregation and neurotoxicity of...

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PMID: 20590832
DOI: 10.1111/j.1447-0594.2010.00598.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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