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Article

Mutant presenilin 2 increases acetylcholinesterase activity in neuronal cells.

Archives of pharmacal research - 1 Sept 2005

Nguyen Hong Nga, Hwang Dae Youn, Kim Young Kyu, Yoon Do Young, Kim Jae Hwa, Lee Moon Soon, Lee Myung Koo, Yun Yeo Pyo, Oh Ki Wan, Hong Jin Tae

Abstract excerpt

A presenilin 2 mutation is believed to be involved in the development of Alzheimer's disease. In addition, transgenic mice with a presenilin 2 mutation have been reported to have learning and memory impairments. In this study, exposing PC12 cells expressing mutant presenilin 2 to 50 microM AP25-35, 30 mM L-glutamate and 50 microM H2O2 caused a significant increase in acetylcholine esterase activity. An in vivo...

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Identifiers

PMID: 16212240
DOI: 10.1007/BF02977404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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