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Article

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2004

Barnham Kevin J, Haeffner Fredrik, Ciccotosto Giuseppe D, Curtain Cyril C, Tew Deborah, Mavros Christine, Beyreuther Konrad, Carrington Darryl, Masters Colin L, Cherny Robert A, Cappai Roberto, Bush Ashley I

Abstract excerpt

Alzheimer's disease (AD) is characterized by the presence of neurofibrillary tangles and amyloid plaques, which are abnormal protein deposits. The major constituent of the plaques is the neurotoxic beta-amyloid peptide (Abeta); the genetics of familial AD support a direct role for this peptide in AD. Abeta neurotoxicity is linked to hydrogen peroxide formation. Abeta coordinates the redox active transition...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15231727
DOI: 10.1096/fj.04-1890fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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