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Article

Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.

ACS chemical neuroscience - 19 Sept 2012

Izuo Naotaka, Kume Toshiaki, Sato Mizuho, Murakami Kazuma, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori

Abstract excerpt

The 42-mer amyloid β-protein (Aβ42) aggregates to form soluble oligomers that cause memory loss and synaptotoxicity in Alzheimer's disease (AD). Oxidative stress is closely related to the pathogenesis of AD. We previously identified the toxic conformer of Aβ42 with a turn at positions 22 and 23 ("toxic turn") by solid-state NMR and demonstrated that a monoclonal antibody (11A1) against the toxic turn in Aβ42...

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Identifiers

PMID: 23019494
DOI: 10.1021/cn300033k
PMCID: PMC3447395

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