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Article

Oxidative modification of cysteine 111 promotes disulfide bond-independent aggregation of SOD1.

Neurochemical research - 1 Apr 2012

Chen Xueping, Shang Huifang, Qiu Xiaozhong, Fujiwara Noriko, Cui Liying, Li Xin-Min, Gao Tian-Ming, Kong Jiming

Abstract excerpt

Converging evidence indicates that SOD1 aggregation is a common feature of mutant SOD1-linked fALS, and seems to be directly related to the gain-of-function toxic property. However, the mechanism inducing the aggregation is not understood. To study the contribution of oxidative modification of cy...

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Source

Identifiers

PMID: 22219129
DOI: 10.1007/s11064-011-0679-8

Genes

SOD1
SDS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22219129-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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