Article

Priming cell-degradable ubiquitination of Aβ42 with molecular crosstalk

2025-03-25

Abstract excerpt

<title>Abstract</title> <p> Cell-degradable ubiquitin (Ub) linkages are crucial for breaking down abnormal proteins. However, K48-linked ubiquitination <bold>—</bold> a canonical Ub linkage driven by a Ub variant that becomes predominant with aging <bold>—</bold> impedes proteasome function, leading to the accumulation of toxic amyloid-beta 42 (Aβ42) in Alzheimer’s disease (AD). We utilized a catalytic Ub-do...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd6633eb-770b-5097-8fc5-9f080267818e
DOI: 10.21203/rs.3.rs-5961309/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Priming cell-degradable ubiquitination of Aβ42 with molecular crosstalkDOI 10.21203/rs.3.rs-5961309/v1Read

Misfolded amyloid β-42 induced impairment of the endosomal-lysosomal pathway revealed by real-time optical monitoringSemantic proximity Read

Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors.Semantic proximity Read

Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage.Semantic proximity Read

Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s diseaseSemantic proximity Read

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide.Semantic proximity Read

Dual-action peptide shuttles rescue Cu-amyloid-β-induced neurotoxicity and relocate Cu intracellularlySemantic proximity Read

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s A <i>β</i> 42 peptideSemantic proximity Read

Differential ubiquitination as an effective strategy employed by Blood-Brain Barrier for prevention of bacterial transcytosisSemantic proximity Read

Synthesis of amyloid beta peptide 1-42 (E22Delta) click peptide: pH-triggered in situ production of its native form.Semantic proximity Read

Endo-lysosomal Aβ concentration and pH enable formation of Aβ oligomers that potently induce Tau missortingSemantic proximity Read

Injectable borax-loaded alginate hydrogels reduce muscle atrophy, modulate inflammation, and generate neuroprotection in the SOD1 <sup>G93A</sup> mouse model of ALS via activation of the IGF–Akt–mTOR axis pathwaySemantic proximity Read

Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?Semantic proximity Read