Inhibitory effects of curcumin on H2O2-induced cell damage and APP expression and processing in SH-SY5Y cells transfected with APP gene with Swedish mutation.

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder, and the pathological mechanism of the disease is still far to understand. According to the amyloid cascade hypothesis in AD, Amyloid-β (Aβ) is considered as a key substance that contributes AD development. Aβ is a β-cleaving product from Amyloid-β protein precursor (APP). Mutations of APP including APPKM670/671670NL (Swedish mutation) result in Aβ...

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