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Article

The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity.

Journal of molecular biology - 13 May 2011

Ovchinnikova Oxana Yu, Finder Verena H, Vodopivec Ivana, Nitsch Roger M, Glockshuber Rudi

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cerebral deposition of amyloid fibrils formed by the amyloid β (Aβ) peptide. Aβ has a length of 39-43 amino acid residues; the predominant Aβ isoforms are Aβ1-40 and Aβ1-42. While the majority of AD cases occur spontaneously, a subset of early-onset familial AD cases is caused by mutations in the genes encoding the Aβ precursor protein or...

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PMID: 21402079
DOI: 10.1016/j.jmb.2011.02.049

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