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Article

Charge alterations of E22 enhance the pathogenic properties of the amyloid beta-protein.

Journal of neurochemistry - 1 May 2000

Melchor J P, McVoy L, Van Nostrand W E

Abstract excerpt

Cerebral amyloid angiopathy (CAA) due to amyloid beta-protein (Abeta) is a key pathological feature of patients with Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D). The CAA in these disorders is characterized by deposition of Abeta in the smooth muscle cells within the cerebral vessel wall. Recently, a new mutation in Abeta, E22K, was identified in several Italian...

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Source

Identifiers

PMID: 10800967
DOI: 10.1046/j.1471-4159.2000.0742209.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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