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Article

APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer's Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression.

International journal of molecular sciences - 31 Oct 2022

Maki Takahito, Sawahata Masahito, Akutsu Ichiro, Amaike Shohei, Hiramatsu Genki, Uta Daisuke, Izuo Naotaka, Shimizu Takahiko, Irie Kazuhiro, Kume Toshiaki

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that requires further pathological elucidation to establish effective treatment strategies. We previously showed that amyloid β (Aβ) toxic conformer with a turn at positions 22-23 is essential for forming highly toxic oligomers. In the present study, we evaluated phenotypic changes with aging in AD model AppNL-P-F/NL-P-F (NL-P-F) mice with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36362046
DOI: 10.3390/ijms232113259
PMCID: PMC9654501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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