Article
The effect of sample size on polygenic hazard models for prostate cancer.
European journal of human genetics : EJHG - 1 Oct 2020
Karunamuni Roshan A, Huynh-Le Minh-Phuong, Fan Chun C, Eeles Rosalind A, Easton Douglas F, Kote-Jarai ZSofia, Amin Al Olama Ali, Benlloch Garcia Sara, Muir Kenneth, Gronberg Henrik, Wiklund Fredrik, Aly Markus, Schleutker Johanna, Sipeky Csilla, Tammela Teuvo L J, Nordestgaard Børge G, Key Tim J, Travis Ruth C, Neal David E, Donovan Jenny L, Hamdy Freddie C, Pharoah Paul, Pashayan Nora, Khaw Kay-Tee, Thibodeau Stephen N, McDonnell Shannon K, Schaid Daniel J, Maier Christiane, Vogel Walther, Luedeke Manuel, Herkommer Kathleen, Kibel Adam S, Cybulski Cezary, Wokolorczyk Dominika, Kluzniak Wojciech, Cannon-Albright Lisa, Brenner Hermann, Schöttker Ben, Holleczek Bernd, Park Jong Y, Sellers Thomas A, Lin Hui-Yi, Slavov Chavdar, Kaneva Radka, Mitev Vanio, Batra Jyotsna, Clements Judith A, Spurdle Amanda, Teixeira Manuel R, Paulo Paula, Maia Sofia, Pandha Hardev, Michael Agnieszka, Mills Ian G, Andreassen Ole A, Dale Anders M, Seibert Tyler M
Abstract excerpt
We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 SNPs per subject, and was split into training and testing sets. Established-SNP models considered 65 SNPs that had been previously associated with prostate cancer. Discovery-SNP models used...
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