Article

The effect of sample size on polygenic hazard models for prostate cancer

2019-06-21

Abstract excerpt

We aimed to determine the effect of sample size on performance of polygenic hazard score (PHS) models in predicting the age at onset of prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 SNPs per subject, and was split into training (34,444 samples) and testing (6,417 samples) sets. Two PHS model-building strategies were investigated. Establi...

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Literature Corpus work: 4a40a42c-6f6f-59b7-bad3-9554c1bdc468
DOI: 10.1101/679092

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