Article
Common genetic and clinical risk factors: association with fatal prostate cancer in the Cohort of Swedish Men.
Prostate cancer and prostatic diseases - 1 Sept 2021
Huynh-Le Minh-Phuong, Karunamuni Roshan, Fan Chun Chieh, Thompson Wesley K, Muir Kenneth, Lophatananon Artitaya, Tye Karen, Wolk Alicja, Håkansson Niclas, Mills Ian G, Andreassen Ole A, Dale Anders M, Seibert Tyler M
Abstract excerpt
BACKGROUND: Clinical variables-age, family history, genetics-are used for prostate cancer risk stratification. Recently, polygenic hazard scores (PHS46, PHS166) were validated as associated with age at prostate cancer diagnosis. While polygenic scores are associated with all prostate cancer (not specific for fatal cancers), PHS46 was also associated with age at prostate cancer death. We evaluated if adding PHS to...
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