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Article

A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Apr 2021

Thomas Cameron D, Parvataneni Hari K, Gray Chancellor F, Deen Justin T, Prieto Hernan A, Pulido Luis F, Elsey Amanda R, Elwood Erica N, Starostik Petr, Gong Yan, Fillingim Roger B, Johnson Julie A, Cavallari Larisa H

Abstract excerpt

PURPOSE: Cytochrome P450 2D6 (CYP2D6) genotype-guided opioid prescribing is limited. The purpose of this type 2 hybrid implementation-effectiveness trial was to evaluate the feasibility of clinically implementing CYP2D6-guided postsurgical pain management and determine that such an approach did not worsen pain control. METHODS: Adults undergoing total joint arthroplasty were randomized 2:1 to genotype-guided or...

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Share to Analgesics, Opioid
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pain, Postoperative

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Source

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Identifiers

PMID: 33420349
DOI: 10.1038/s41436-020-01050-4
PMCID: PMC8525217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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