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Article

Pharmacogenetics-guided analgesics in major abdominal surgery: Further benefits within an enhanced recovery protocol.

American journal of surgery - 1 Mar 2017

Senagore Anthony J, Champagne Bradley J, Dosokey Eslam, Brady Justin, Steele Scott R, Reynolds Harry L, Stein Sharon L, Delaney Conor P

Abstract excerpt

OBJECTIVE: Effective, narcotic sparing analgesia is a major component of Enhanced Recovery Protocols (ERP), however the risk of poor analgesia and opioid related side effects (ORADE) remains an issue related to poor outcomes and satisfaction, and is strongly related to the risk of narcotic dependence after surgery. A variety of genes can impact narcotic and non-steroidal (NSAID) drug efficacy including: the CYP...

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Topics

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Share to Analgesics
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

Share to Laparoscopy

Share to Pain, Postoperative

Share to Receptors, Opioid, mu

Share to Rectum

Source

Identifiers

PMID: 27955884
DOI: 10.1016/j.amjsurg.2016.11.008

Genes

ABCB1
COMT
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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